Ontology highlight
ABSTRACT:
SUBMITTER: Takasugi M
PROVIDER: S-EPMC5467215 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Takasugi Masaki M Okada Ryo R Takahashi Akiko A Virya Chen David D Watanabe Sugiko S Hara Eiji E
Nature communications 20170606
Cellular senescence prevents the proliferation of cells at risk for neoplastic transformation. However, the altered secretome of senescent cells can promote the growth of the surrounding cancer cells. Although extracellular vesicles (EVs) have emerged as new players in intercellular communication, their role in the function of senescent cell secretome has been largely unexplored. Here, we show that exosome-like small EVs (sEVs) are important mediators of the pro-tumorigenic function of senescent ...[more]