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Extracellular vesicles secreted from senescent cancer cells promote colorectal cancer progression through SERPINE1

ABSTRACT: By the iTRAQ-based quantitative proteomics, we assessed the protein cargos inside EVs secreted from colorectal cancer cells

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Colon

DISEASE(S): Colon Cancer

SUBMITTER: dan zhang

LAB HEAD: Fuxiang zhou

PROVIDER: PXD047062 | Pride | 2024-04-06

REPOSITORIES: Pride

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			Action	DRS
	22P2094_22P2026_1.raw	Raw
	22P2094_22P2026_10.raw	Raw
	22P2094_22P2026_11.raw	Raw
	22P2094_22P2026_12.raw	Raw
	22P2094_22P2026_13.raw	Raw

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Publications

Axenfeld-Rieger syndrome in monozygotic twin brothers: Case report.

Akcay Betul Ilkay Sezgin BIS Kardes Esra E Limon Utku U

Northern clinics of Istanbul 20220815 4

Axenfeld-Rieger syndrome (ARS) is a genetic disease affecting multiple organ systems. In the eye, it is associated with anterior segment dysgenesis with a high risk for glaucoma. Dental anomalies, cardiovascular malformations, hypospadias, and craniofacial abnormalities are other associated systemic conditions. Five years old monozygotic twin brothers with ARS were referred to Umraniye Training and Research Hospital, ophthalmology clinic for iris abnormalities. At presentation, pathognomonic com ...[more]

PMID: 36276572

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Proteomic analysis of differentially expressed proteins in the serum of patients with acute renal allograft rejection using iTRAQ labelling technology

Project description:Transplantation is currently the best treatment option for end-stage renal disease (ESRD) patients. However, acute rejection (AR) is the main source of failure in renal transplantation. The current gold standard for diagnosis of AR involves renal biopsy, but it is invasive, time consuming, costly and inconvenient. Sensitive and less invasive detection of AR episodes in renal transplant patients is essential to preserve the allograft function. Here, we applied isobaric tags for relative and absolute quantisation (iTRAQ) mass spectrometry to analyse serum protein expression in AR patients and healthy controls. Overall, 1399 proteins were identified. Using a cut-off of Q<0.05 and a fold change > 1.2 for the expressed variation, 109 proteins showed distinct differential expression between the AR and control groups, of whom 72 were upregulated and 37 were downregulated. Several proteins, such as properdin, keratin 1, lipoprotein (a) and vitamin D-binding protein, may play roles in the pathogenesis of AR. This study focused on iTRAQ-based proteomic profiling of serum samples in AR. Insights from our work might help advance our understanding of the molecular mechanisms of AR and identify potential novel biomarkers of AR for further characterization.

2021-09-08 | PXD015336 | Pride

Proteomic analysis of somatosensory cortex of Pten haploinsufficient mice

Project description:To discover differentially expressed proteins in somatosensory cortex of Pten haploinsufficient mice at adolescence (P30). Result reveals signatures of perturbation of dendritic spine development, keratinization and hamartoma. These are collectively respresentating molecular perturbation of neuropathology of PTEN Harmatoma Tumor Syndrome (PHTS).

2023-04-26 | PXD030573 | Pride

An Isocaloric High-Fat Diet Improves Lifespan in Rats and Drosophila

Project description:The health effect of dietary fat has been one of the most vexing issues in the nutrition field. Few animal studies have examined the impact of high-fat diets on lifespan by controlling energy intake. In this study, we found that compared to a normal diet, an isocaloric high-fat diet (IHF) significantly prolonged lifespan by decreasing the profiles of free fatty acids (FFAs) in serum and multiple tissues by downregulating FFAs anabolism and upregulating catabolism pathways in rats and flies. Proteomics analysis in rats identified PPRC1 as a key protein that was significantly upregulated by nearly 2-fold by IHF, and among the FFAs, only palmitic acid (PA) was robustly and negatively associated with the expression of PPRC1. Using PPRC1 transgenic RNAi/overexpression flies and in vitro experiments, we further demonstrated that IHF significantly reduced PA, which could upregulate PPRC1 through PPARG, resulting in improvements in oxidative stress and inflammation and prolonging lifespan.

2021-01-06 | PXD022585 | Pride

Changes in proteomics of endometrial tissue during secretion of polycystic ovary syndrome may affect endometrial receptivity

Project description:Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies among fertile women. PCOS patients have been confirmed to be accompanied by an increased risk of pregnancy complication, and the exact cause is still unclear. Many factors may cause this situation, and impaired endometrial receptivity could be responsible for adverse pregnancy outcomes in PCOS. Unfortunately, there were still few researches about the molecular mechanisms regarding impaired endometrial receptivity. So we designed this study to explore the secretory endometrial proteome in PCOS patients.

2022-06-09 | PXD024735 | Pride

Liver proteome response of turbot to lysine and leucine in free and dipeptide forms

Project description:In this iTRAQ quantification project, there were 6 Scophthalmus_maximus samples named CAA-1, CAA-2, CAA-3, Lys-Leu-1, Lys-Leu-2, Lys-Leu-3 and we did one technical duplicate experiments. Totally 935928 spectrums were generated, 32261 peptides and 5708 proteins were identified with 1% false discovery rate (FDR).

2021-06-22 | PXD025276 | Pride

Dendrobium officinale seed symbiotic germination iTRAQ

Project description:Mycorrhizal fungi colonize orchid seed and induce the germination. This so-called symbiotic germination is a critical developmental process in the lifecycle of all orchids. However, the molecular changes taking place during the orchid seed symbiotic germination still remains largely unknown. To better understand the molecular mechanism of orchid seed germination, we performed comparative transcriptomic and proteomic analysis on Chinese traditional medicinal orchid plants, Dendrobium officinale to explore protein expression change at the different developmental stages between asymbiotic and symbiotic germination and identify the key proteins regulated symbiotic germination of orchid seeds. iTRAQ analysis from 8 samples identified 2256 plant proteins, of which, 308 proteins were differentially expressed across three developmental stages within asymbiotic or symbiotic accession and 229 proteins are differentially expressed in the symbiotic germination compared to asymbiotic germination. 32 proteins are co-upregulated in both proteomic and transcriptomic level for symbiotic germination compared to asymbiotic germination. Our results revealed that symbiotic germination of D. officinale seeds probably shares the common signal pathway with asymbiotic germination during the early germination stage.

2017-05-12 | PXD006102 | Pride

zebrafish embryos proteome for slbp2 KO F3 and wild type

Project description:zebrafish embryos proteome for slbp2 KO F3 and wild type at 2.5hpf and 3.5hpf, three replicates for every sample. There are 12 samples in total. Then we analyse the different expressed genes and hope to find out clue which result in serious phenotype of slbp2 KO F3.

2018-11-27 | PXD008614 | Pride

iTRAQ-based Quantitative Proteomics Analysis Screen for Critical Proteins during Temperature-Responsive Flowering of Crocus sativus

Project description:To uncover the underlying mechanism of temperature-responsive flowering in Crocus sativus and unveil flowering regulatory proteins, iTRAQ (isobaric tags for relative or absolute quantitation)-based proteomics were applied to study the differences in protein expression profiles in flowering and non-flowering saffron grown at room- and low-temperatures, respectively. A total of 5,624 proteins were identified，and 201 proteins showed differential accumulations between the flowering and non-flowering groups.

2021-09-09 | PXD021020 | Pride

Peanut shell iTRAQ data

Project description:Identification and Quantitation of peanut shell samples in differet treatment conditions.

2020-05-06 | PXD011977 | Pride

Peanut seed iTRAQ project

Project description:Identification and Quantitation of peanut seed samples in differet peanut variety

2020-05-06 | PXD011980 | Pride