Ontology highlight
ABSTRACT:
SUBMITTER: Gao Q
PROVIDER: S-EPMC5467231 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Gao Qian Q Zhang Junfeng J Wang Xiumei X Liu Ying Y He Rongqiao R Liu Xingfeng X Wang Fei F Feng Jing J Yang Dongling D Wang Zhaoqing Z Meng Anming A Yan Xiyun X
Nature communications 20170607
The apical-basal (AB) polarity and planar cell polarity (PCP) provide an animal cell population with different phenotypes during morphogenesis. However, how cells couple these two patterning systems remains unclear. Here we provide in vivo evidence that melanoma cell adhesion molecule (MCAM) coordinates AB polarity-driven lumenogenesis and c-Jun N-terminal kinase (JNK)/PCP-dependent ciliogenesis. We identify that MCAM is an independent receptor of fibroblast growth factor 4 (FGF4), a membrane an ...[more]