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WASH maintains NKp46⁺ ILC3 cells by promoting AHR expression.

ABSTRACT: Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s). WASH deletion impairs the cell pool of NKp46⁺ ILC3s. In NKp46⁺ ILC3s, WASH recruits Arid1a to the Ahr promoter thus activating AHR expression. WASH deletion in ILC3s decreases the number of NKp46⁺ ILC3s. Moreover, Arid1a deletion impedes AHR expression and impairs the maintenance of NKp46⁺ ILC3s. Therefore, WASH-mediated AHR expression has a critical function in the maintenance of NKp46⁺ ILC3s.

SUBMITTER: Xia P

PROVIDER: S-EPMC5467242 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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WASH maintains NKp46+ ILC3 cells by promoting AHR expression.

Xia Pengyan P Liu Jing J Wang Shuo S Ye Buqing B Du Ying Y Xiong Zhen Z Han Ze-Guang ZG Tong Liang L Fan Zusen Z

Nature communications 20170607

Innate lymphoid cells (ILCs) communicate with other haematopoietic and non-haematopoietic cells to regulate immunity, inflammation and tissue homeostasis. How these ILC lineages develop and are maintained is not clear. Here we show that WASH is highly expressed in the nucleus of group 3 ILCs (ILC3s). WASH deletion impairs the cell pool of NKp46+ ILC3s. In NKp46+ ILC3s, WASH recruits Arid1a to the Ahr promoter thus activating AHR expression. WASH deletion in ILC3s decreases ...[more]

PMID: 28589939

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WASH maintains NKp46⁺ ILC3 cells by promoting AHR expression.

Publications

WASH maintains NKp46<sup>+</sup> ILC3 cells by promoting AHR expression.

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