Biocuration in the structure-function linkage database: the anatomy of a superfamily.
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ABSTRACT:
SUBMITTER: Holliday GL
PROVIDER: S-EPMC5467563 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Biocuration in the structure-function linkage database: the anatomy of a superfamily.
Holliday Gemma L GL Brown Shoshana D SD Akiva Eyal E Mischel David D Hicks Michael A MA Morris John H JH Huang Conrad C CC Meng Elaine C EC Pegg Scott C-H SC Ferrin Thomas E TE Babbitt Patricia C PC
Database : the journal of biological databases and curation 20170101 1
With ever-increasing amounts of sequence data available in both the primary literature and sequence repositories, there is a bottleneck in annotating molecular function to a sequence. This article describes the biocuration process and methods used in the structure-function linkage database (SFLD) to help address some of the challenges. We discuss how the hierarchy within the SFLD allows us to infer detailed functional properties for functionally diverse enzyme superfamilies in which all members ...[more]
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