Ontology highlight
ABSTRACT:
SUBMITTER: Wei D
PROVIDER: S-EPMC5468247 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Wei Dian D Hu Meng-Jun MJ Shao Xiao-Xia XX Wang Jia-Hui JH Nie Wei-Han WH Liu Ya-Li YL Xu Zeng-Guang ZG Guo Zhan-Yun ZY
Scientific reports 20170612 1
Relaxin family peptides perform a variety of biological functions by activating four G protein-coupled receptors, namely RXFP1-4. Among these receptors, RXFP3 lacks a specific natural or synthetic agonist at present. A previously designed chimeric R3/I5 peptide, consisting of the B-chain of relaxin-3 and the A-chain of INSL5, displays equal activity towards the homologous RXFP3 and RXFP4. To increase its selectivity towards RXFP3, in the present study we conducted extensive mutagenesis around th ...[more]