Ontology highlight
ABSTRACT:
SUBMITTER: Famulla K
PROVIDER: S-EPMC5469208 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Famulla Kirsten K Sass Peter P Malik Imran I Akopian Tatos T Kandror Olga O Alber Marina M Hinzen Berthold B Ruebsamen-Schaeff Helga H Kalscheuer Rainer R Goldberg Alfred L AL Brötz-Oesterhelt Heike H
Molecular microbiology 20160401 2
The Clp protease complex in Mycobacterium tuberculosis is unusual in its composition, functional importance and activation mechanism. Whilst most bacterial species contain a single ClpP protein that is dispensable for normal growth, mycobacteria have two ClpPs, ClpP1 and ClpP2, which are essential for viability and together form the ClpP1P2 tetradecamer. Acyldepsipeptide antibiotics of the ADEP class inhibit the growth of Gram-positive firmicutes by activating ClpP and causing unregulated protei ...[more]