A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.
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ABSTRACT:
SUBMITTER: Essex-Lopresti AE
PROVIDER: S-EPMC547011 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Publications
A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.
Essex-Lopresti Angela E AE Boddey Justin A JA Thomas Richard R Smith Martin P MP Hartley M Gill MG Atkins Timothy T Brown Nat F NF Tsang Chuk Hai CH Peak Ian R A IR Hill Jim J Beacham Ifor R IR Titball Richard W RW
Infection and immunity 20050201 2
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence. ...[more]
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