Ontology highlight
ABSTRACT:
SUBMITTER: Trott J
PROVIDER: S-EPMC5470345 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Trott Jamie J Tan Ee Kim EK Ong Sheena S Titmarsh Drew M DM Denil Simon L I J SLIJ Giam Maybelline M Wong Cheng Kit CK Wang Jiaxu J Shboul Mohammad M Eio Michelle M Cooper-White Justin J Cool Simon M SM Rancati Giulia G Stanton Lawrence W LW Reversade Bruno B Dunn N Ray NR
Stem cell reports 20170601 6
Pluripotent stem cells have been proposed as an unlimited source of pancreatic β cells for studying and treating diabetes. However, the long, multi-step differentiation protocols used to generate functional β cells inevitably exhibit considerable variability, particularly when applied to pluripotent cells from diverse genetic backgrounds. We have developed culture conditions that support long-term self-renewal of human multipotent pancreatic progenitors, which are developmentally more proximal t ...[more]