Gene-Hormone Therapy Interaction and Fracture Risk in Postmenopausal Women.
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ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC5470770 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Gene-Hormone Therapy Interaction and Fracture Risk in Postmenopausal Women.
Wang Youjin Y Wactawski-Wende Jean J Sucheston-Campbell Lara E LE Preus Leah L Hovey Kathleen M KM Nie Jing J Jackson Rebecca D RD Handelman Samuel K SK Nassir Rami R Crandall Carolyn J CJ Ochs-Balcom Heather M HM
The Journal of clinical endocrinology and metabolism 20170601 6
<h4>Context</h4>Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored.<h4>Objective</h4>The objective was to test an interaction between genetic susceptibility and HT on fracture risk.<h4>Design</h4>We constructed two weighted genetic risk scores (GRSs) based on 16 fracture-associated variants (Fx-GRSs) and 50 bone mineral density variants (BMD-GRSs). ...[more]
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