Gene-Hormone Therapy Interaction and Fracture Risk in Postmenopausal Women.

ABSTRACT:

Context

Evidence supports a protective effect of menopausal hormone therapy (HT) on bone. However, whether genetic susceptibility modifies the association of HT and fracture risk is not sufficiently explored.

Objective

The objective was to test an interaction between genetic susceptibility and HT on fracture risk.

Design

We constructed two weighted genetic risk scores (GRSs) based on 16 fracture-associated variants (Fx-GRSs) and 50 bone mineral density variants (BMD-GRSs). We used Cox regression to estimate the main effects of GRSs and their interactions with HT on fracture risk. We estimated the relative excess risk due to interaction (RERI) as a measure of additive interaction. We also used the case-only approach to test for a multiplicative interaction.

Setting<

SUBMITTER: Wang Y 

PROVIDER: S-EPMC5470770 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature