Interaction between postmenopausal hormone therapy and diabetes on cataract.
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ABSTRACT: Objective
We investigated whether postmenopausal hormone therapy (HT) use interacts with diabetes, a risk factor for several age-related eye diseases.Methods
A cross-sectional analysis of women involved in the Canadian Longitudinal Study on Aging was performed. The random sample comprised of 15,320 community-dwelling women between ages 45 and 85 years old sampled from areas adjacent to 11 data collection centers across Canada. Information on menopausal status and HT were collected by self-report. Data on diabetes and eye disease were obtained by self-report of a physician diagnosis. Multivariable logistic regression was used.Results
After adjusting for demographic, lifestyle, and health variables, a multiplicative interaction was identified such that HT use for 10 years or more was associated with a much higher odds of a report of cataract in women with type 2 diabetes (odds ratio?=?2.44, 95% confidence interval 1.49, 3.99) but not in long-term HT users with no diabetes (odds ratio?=?1.03, 95% confidence interval 0.87, 1.21) (interaction term P value?=?0.013). HT use was not associated with glaucoma or macular degeneration.Conclusions
Long-term HT use and type 2 diabetes interact in their relationship with cataract. This novel finding should be confirmed. If confirmed, women with type 2 diabetes should be informed that long-term HT use increases their risk of cataract. : Video Summary:http://links.lww.com/MENO/A519.
SUBMITTER: Costanian C
PROVIDER: S-EPMC7050793 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Interaction between postmenopausal hormone therapy and diabetes on cataract.
Costanian Christy C Aubin Marie-Josée MJ Buhrmann Ralf R Freeman Ellen E EE
Menopause (New York, N.Y.) 20200301 3
<h4>Objective</h4>We investigated whether postmenopausal hormone therapy (HT) use interacts with diabetes, a risk factor for several age-related eye diseases.<h4>Methods</h4>A cross-sectional analysis of women involved in the Canadian Longitudinal Study on Aging was performed. The random sample comprised of 15,320 community-dwelling women between ages 45 and 85 years old sampled from areas adjacent to 11 data collection centers across Canada. Information on menopausal status and HT were collecte ...[more]
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