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High TGF-?1 expression predicts poor disease prognosis in hepatocellular carcinoma patients.


ABSTRACT: Transforming growth factor beta (TGF-?) promotes the pathogenesis of hepatocellular carcinoma (HCC). We evaluated the associations between TGF-?1 expression and clinicopathological parameters in HCC patients from The Cancer Genome Atlas (TCGA), as well as the prognostic power of TGF-?1 expression. Eligible studies were retrieved from several databases, and effects (hazard ratios (HRs) with 95% confidence intervals (CIs)) for overall survival (OS), disease-free survival (DFS), recurrence-free survival (RFS), metastasis-free survival (MFS), and progression-free survival (PFS) were pooled to assess the prognostic ability of TGF-?1 expression in HCC patients. Twelve qualified articles and our TCGA data comprising 2,021 HCC patients were incorporated. In the TCGA analysis, HCC patients with higher TGF-?1 expression presented a shorter OS than those with lower TGF-?1 expression (HR = 1.42, p < 0.05). In the meta-analysis, univariate analyses showed that HCC patients with higher TGF-?1 expression had a shorter OS (pooling HR = 1.71, p < 0.01) and DFS/RFS/MFS/PFS (pooling HR = 1.60, p < 0.01) than those with lower TGF-?1 expression. In conclusion, our results suggested that high TGF-?1 expression promotes a poor prognosis in HCC patients.

SUBMITTER: Peng L 

PROVIDER: S-EPMC5470976 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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High TGF-β1 expression predicts poor disease prognosis in hepatocellular carcinoma patients.

Peng Li L   Yuan Xiao-Qing XQ   Zhang Chao-Yang CY   Ye Fei F   Zhou Hui-Fang HF   Li Wen-Ling WL   Liu Zhao-Yang ZY   Zhang Ya-Qin YQ   Pan Xi X   Li Guan-Cheng GC  

Oncotarget 20170501 21


Transforming growth factor beta (TGF-β) promotes the pathogenesis of hepatocellular carcinoma (HCC). We evaluated the associations between TGF-β1 expression and clinicopathological parameters in HCC patients from The Cancer Genome Atlas (TCGA), as well as the prognostic power of TGF-β1 expression. Eligible studies were retrieved from several databases, and effects (hazard ratios (HRs) with 95% confidence intervals (CIs)) for overall survival (OS), disease-free survival (DFS), recurrence-free sur  ...[more]

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