Ontology highlight
ABSTRACT:
SUBMITTER: Hashimoto-Hill S
PROVIDER: S-EPMC5471139 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Hashimoto-Hill S S Friesen L L Kim M M Kim C H CH
Mucosal immunology 20161214 4
The intestinal environment harbors a large number of activated T cells, which are potentially inflammatory. To prevent inflammatory responses, intestinal T cells are controlled by various tolerogenic mechanisms, including T-cell apoptosis. We investigated the expression mechanism and function of the purinergic receptor P2X7 in contraction of intestinal CD4<sup>+</sup> effector T cells. We found that P2X7 upregulation on CD4<sup>+</sup> effector T cells is induced by retinoic acid through retinoi ...[more]