Ontology highlight
ABSTRACT:
SUBMITTER: Vandersarren L
PROVIDER: S-EPMC5471230 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Vandersarren Lana L Bosteels Cedric C Vanheerswynghels Manon M Moon James J JJ Moon James J JJ Easton Andrew J AJ Van Isterdael Gert G Janssens Sophie S Lambrecht Bart N BN van Helden Mary J MJ
Scientific reports 20170614 1
Pneumonia virus of mice (PVM) infection has been widely used as a rodent model to study the closely related human respiratory syncytial virus (hRSV). While T cells are indispensable for viral clearance, they also contribute to immunopathology. To gain more insight into mechanistic details, novel tools are needed that allow to study virus-specific T cells in C57BL/6 mice as the majority of transgenic mice are only available on this background. While PVM-specific CD8 T cell epitopes were recently ...[more]