Ontology highlight
ABSTRACT:
SUBMITTER: Campbell VL
PROVIDER: S-EPMC7839664 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Campbell Victoria L VL Nguyen LeAnn L Snoey Elise E McClurkan Christopher L CL Laing Kerry J KJ Dong Lichun L Sette Alessandro A Lindestam Arlehamn Cecilia S CS Altmann Danny M DM Boyton Rosemary J RJ Roby Justin A JA Gale Michael M Stone Mars M Busch Michael P MP Norris Phillip J PJ Koelle David M DM
ImmunoHorizons 20200804 8
Zika virus (ZIKV) is a mosquito-borne pathogen that caused an epidemic in 2015-2016. ZIKV-specific T cell responses are functional in animal infection models, and helper CD4 T cells promote avid Abs in the vaccine context. The small volumes of blood available from field research limit the determination of T cell epitopes for complex microbes such as ZIKV. The goal of this project was efficient determination of human ZIKV CD4 T cell epitopes at the whole proteome scale, including validation of re ...[more]