Ontology highlight
ABSTRACT:
SUBMITTER: Bradley T
PROVIDER: S-EPMC5472724 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Bradley Todd T Pollara Justin J Santra Sampa S Vandergrift Nathan N Pittala Srivamshi S Bailey-Kellogg Chris C Shen Xiaoying X Parks Robert R Goodman Derrick D Eaton Amanda A Balachandran Harikrishnan H Mach Linh V LV Saunders Kevin O KO Weiner Joshua A JA Scearce Richard R Sutherland Laura L LL Phogat Sanjay S Tartaglia Jim J Reed Steven G SG Hu Shiu-Lok SL Theis James F JF Pinter Abraham A Montefiori David C DC Kepler Thomas B TB Peachman Kristina K KK Rao Mangala M Michael Nelson L NL Suscovich Todd J TJ Alter Galit G Ackerman Margaret E ME Moody M Anthony MA Liao Hua-Xin HX Tomaras Georgia G Ferrari Guido G Korber Bette T BT Haynes Barton F BF
Nature communications 20170608
The RV144 Thai trial HIV-1 vaccine of recombinant poxvirus (ALVAC) and recombinant HIV-1 gp120 subtype B/subtype E (B/E) proteins demonstrated 31% vaccine efficacy. Here we design an ALVAC/Pentavalent B/E/E/E/E vaccine to increase the diversity of gp120 motifs in the immunogen to elicit a broader antibody response and enhance protection. We find that immunization of rhesus macaques with the pentavalent vaccine results in protection of 55% of pentavalent-vaccine-immunized macaques from simian-hum ...[more]