Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy.
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ABSTRACT:
SUBMITTER: Wong D
PROVIDER: S-EPMC5473160 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
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Novel Beta-Lactamase Inhibitors: Unlocking Their Potential in Therapy.
Wong Darren D van Duin David D
Drugs 20170401 6
Carbapenem-resistant Enterobacteriaceae are amongst the most feared pathogens due to severely limited treatment options. In response to this threat, three novel β-lactamase inhibitors have been developed in an attempt to reinvigorate and sustain our current antimicrobial therapies. Avibactam, vaborbactam, and relebactam are inhibitor agents with high affinity to Ambler class A and C β-lactamases and favorable outcomes in current clinical trials. However, although they do possess key similarities ...[more]
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