Ontology highlight
ABSTRACT:
SUBMITTER: Cobos Caceres C
PROVIDER: S-EPMC5473231 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cobos Caceres Claudia C Bansal Paramjit S PS Navarro Severine S Wilson David D Don Laurianne L Giacomin Paul P Loukas Alex A Daly Norelle L NL
The Journal of biological chemistry 20170504 24
Inflammatory bowel diseases (IBDs) are a set of complex and debilitating diseases for which there is no satisfactory treatment. Recent studies have shown that small peptides show promise for reducing inflammation in models of IBD. However, these small peptides are likely to be unstable and rapidly cleared from the circulation, and therefore, if not modified for better stability, represent non-viable drug leads. We hypothesized that improving the stability of these peptides by grafting them into ...[more]