Circulating Apolipoprotein A-IV presurgical levels are associated with improvement in insulin sensitivity after Roux-en-Y gastric bypass surgery.

ABSTRACT:

Background

Apolipoprotein A-IV (ApoA-IV) has been shown to be involved in obesity and diabetes pathogenesis in animal studies, but its role in humans is uncertain.

Objectives

The objective of this study was to determine the relation of ApoA-IV with changes in glucose metabolism and weight after bariatric surgery.

Setting

University Hospital.

Methods

The patients (n = 49) included lean controls (n = 8) and patients before and after a mean of 7 months after laparoscopic adjustable gastric banding (LAGB, n = 12), laparoscopic Roux-en-Y gastric bypass (RYGB, n = 22), or laparoscopic sleeve gastrectomy (SG, n = 11). ApoA-IV and other hormone assays were performed in the fasting and the postprandial state. Pearson's correlation analyses controlled for baseline BMI an

SUBMITTER: Rao R 

PROVIDER: S-EPMC5473622 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature