Dataset Information

Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.

ABSTRACT:

Background

Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells.

Methods

Of 1782 reproductive-aged women detected pregestational serum androgen, 1406 were pregnant between 2005 and 2010. Of 1198 women who delivered, 1116 eligible mothers (147 with hyperandrogenism and 969 normal) were recruited. 1216 children (156 children born to mothers with hyperandrogenism and 1060 born to normal mother) were followed up their glycometabolism in mean age of 5years. Imprinting genes of oocyte from mothers and lymphocytes from children were examined. A pregestational hyperandrogenism rat model was also established.

Findings

Children born to women with hyperandrogenism showed increased serum fasting glucose and insulin levels, and were more prone to prediabetes (adjusted RR: 3.98 (95%CI 1.16-13.58)). Oocytes from women with hyperandrogenism showed increased insulin-like growth factor 2 (IGF2) expression. Lymphocytes from their children also showed increased IGF2 expression and decreased IGF2 methylation. Treatment of human oocytes with dihydrotestosterone upregulated IGF2 and downregulated DNMT3a levels. In rat, pregestational hyperandrogenism induced diabetic phenotypes and impaired insulin secretion in offspring. In consistent with the findings in human, hyperandrogenism also increased Igf2 expression and decreased DNMT3a in rat oocytes. Importantly, the same altered methylation signatures of Igf2 were identified in the offspring pancreatic islets.

Interpretation

Pregestational hyperandrogenism may predispose offspring to glucose metabolism disorder via epigenetic oocyte inheritance. Clinical trial registry no.: ChiCTR-OCC-14004537; www.chictr.org.

SUBMITTER: Tian S

PROVIDER: S-EPMC5474435 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.

Tian Shen S Lin Xian-Hua XH Xiong Yi-Meng YM Liu Miao-E ME Yu Tian-Tian TT Lv Min M Zhao Wei W Xu Gu-Feng GF Ding Guo-Lian GL Xu Chen-Ming CM Jin Min M Feng Chun C Wu Yan-Ting YT Tan Ya-Jing YJ Gao Qian Q Zhang Jian J Li Cheng C Ren Jun J Jin Lu-Yang LY Chen Bin B Zhu Hong H Zhang Xue-Ying XY Chen Song-Chang SC Liu Xin-Mei XM Liu Ye Y Zhang Jun-Yu JY Wang Li L Zhang Ping P Chen Xiao-Jun XJ Jin Li L Chen Xi X Meng Yi-Cong YC Wu Dan-Dan DD Lin Hui H Yang Qian Q Zhou Cheng-Liang CL Li Xin-Zhu XZ Wang Yi-Yu YY Xiang Yu-Qian YQ Liu Zhi-Wei ZW Gao Ling L Chen Lu-Ting LT Pan Hong-Jie HJ Li Rong R Zhang Fang-Hong FH Xing Lan-Feng LF Zhu Yi-Min YM Klausen Christian C Leung Peter C K PCK Li Ju-Xue JX Sun Fei F Sheng Jian-Zhong JZ Huang He-Feng HF

EBioMedicine 20170111

<h4>Background</h4>Excessive androgen exposure during pregnancy has been suggested to induce diabetic phenotypes in offspring in animal models. The aim of this study was to investigate whether pregestational maternal hyperandrogenism in human influenced the glucose metabolism in offspring via epigenetic memory from mother's oocyte to child's somatic cells.<h4>Methods</h4>Of 1782 reproductive-aged women detected pregestational serum androgen, 1406 were pregnant between 2005 and 2010. Of 1198 wome ...[more]

PMID: 28111236

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Project description:Previous research suggests that the birth of a preterm child with very low birth weight (VLBW; <1,500 g) can be traumatic for both parents and lead to short-term consequences like clinical levels of posttraumatic stress symptoms (PTSS) or even to the development of a Posttraumatic Stress Disorder (PTSD). However, little is known about possible mid- and long-term psychological consequences in affected parents. The purpose of this study were (a) to examine the prevalence of parental birth-related PTSS and PTSD in a group of parents with VLBW preterm infants compared to parents of full-term infants 5 years after birth and (b) to investigate potential associations with risk factors for parental PTSS at 5 years postpartum. Perinatal factors (VLBW preterm or term, perceived stress during birth), psychological factors (perceived social support and PTSS 4-6 weeks postpartum, psychiatric lifetime diagnosis) and sociodemographic characteristics (number of children, singleton or multiple birth, socio-economic status), were included in the analysis. The sample consisted of 144 families (77 VLBW, 67 term birth) who participated in the prospective longitudinal cohort study "Hamburg study of VLBW and full-term infant development" (HaFEn-study) and were initially recruited at three perinatal care centers in Hamburg, Germany. PTSD prevalence and PTSS of mothers and fathers were assessed with the Impact of Event Scale-Revised (IES-R), social support with the Questionnaire of Social Support (SOZU-K-22), and lifetime psychiatric diagnoses with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (SCID-I). Data were analyzed by hierarchic multiple regression analyses. Results showed that 5 years after birth none of the parents fulfilled the criteria for a birth-related PTSD diagnosis. For mothers, postnatal PTSS and a VLBW preterm birth significantly predicted PTSS 5 years postpartum. For fathers, psychiatric lifetime diagnosis and postnatal PTSS significantly predicted PTSS 5 years after birth. Early identification of parents with higher risk of PTSS, especially after VLBW preterm birth, and their clinical needs seems beneficial to reduce the risk of long-term consequences. More research is needed on the paternal perspective and on potential effects of preterm birth on both parents and their children's mental health outcomes.

Dataset Information

Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.

Background

Methods

Findings

Interpretation

Publications

Prevalence of Prediabetes Risk in Offspring Born to Mothers with Hyperandrogenism.

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