Ontology highlight
ABSTRACT:
SUBMITTER: Hwu JR
PROVIDER: S-EPMC5474666 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
ChemistryOpen 20170505 3
Benzyne was developed as a reducing agent in the key step of converting amino sugars and ketoses into deoxy sugars, which occur widely in natural products. Many deoxy sugars exhibit antibiotic and anticancer activities, and furthermore, they play essential biological roles. By treatment with CS<sub>2</sub> and then Ac<sub>2</sub>O, amino sugars and ketoses were converted into the corresponding 1,3-thiazolidine-2-thiones. In the key step, these intermediates were treated with 2-trimethylsilylphen ...[more]