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Synthesis of indolines via a domino Cu-catalyzed amidation/cyclization reaction.

ABSTRACT: A highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions.

SUBMITTER: Minatti A

PROVIDER: S-EPMC2489202 | biostudies-literature | 2008 Jul

REPOSITORIES: biostudies-literature

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Synthesis of indolines via a domino Cu-catalyzed amidation/cyclization reaction.

Minatti Ana A Buchwald Stephen L SL

Organic letters 20080604 13

A highly efficient one-pot procedure for the synthesis of indolines and their homologues based on a domino Cu-catalyzed amidation/nucleophilic substitution reaction has been developed. Substituted 2-iodophenethyl mesylates and related compounds afforded the corresponding products in excellent yields. No erosion of optical purity was observed when transforming enantiomerically pure mesylates under the reaction conditions. ...[more]

PMID: 18522394

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