Reproductive fitness and genetic risk of psychiatric disorders in the general population.
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ABSTRACT:
SUBMITTER: Mullins N
PROVIDER: S-EPMC5474730 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Reproductive fitness and genetic risk of psychiatric disorders in the general population.
Mullins Niamh N Ingason Andrés A Porter Heather H Euesden Jack J Gillett Alexandra A Ólafsson Sigurgeir S Gudbjartsson Daniel F DF Lewis Cathryn M CM Sigurdsson Engilbert E Saemundsen Evald E Gudmundsson Ólafur Ó ÓÓ Frigge Michael L ML Kong Augustine A Helgason Agnar A Walters G Bragi GB Gustafsson Omar O Stefansson Hreinn H Stefansson Kari K
Nature communications 20170613
The persistence of common, heritable psychiatric disorders that reduce reproductive fitness is an evolutionary paradox. Here, we investigate the selection pressures on sequence variants that predispose to schizophrenia, autism, bipolar disorder, major depression and attention deficit hyperactivity disorder (ADHD) using genomic data from 150,656 Icelanders, excluding those diagnosed with these psychiatric diseases. Polygenic risk of autism and ADHD is associated with number of children. Higher po ...[more]
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