Ontology highlight
ABSTRACT:
SUBMITTER: Ogrodnik M
PROVIDER: S-EPMC5474745 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature communications 20170613
The incidence of non-alcoholic fatty liver disease (NAFLD) increases with age. Cellular senescence refers to a state of irreversible cell-cycle arrest combined with the secretion of proinflammatory cytokines and mitochondrial dysfunction. Senescent cells contribute to age-related tissue degeneration. Here we show that the accumulation of senescent cells promotes hepatic fat accumulation and steatosis. We report a close correlation between hepatic fat accumulation and markers of hepatocyte senesc ...[more]