Ontology highlight
ABSTRACT:
SUBMITTER: Grassme H
PROVIDER: S-EPMC5475347 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Grassmé Heike H Henry Brian B Ziobro Regan R Becker Katrin Anne KA Riethmüller Joachim J Gardner Aaron A Seitz Aaron P AP Steinmann Joerg J Lang Stephan S Ward Christopher C Schuchman Edward H EH Caldwell Charles C CC Kamler Markus M Edwards Michael J MJ Brodlie Malcolm M Gulbins Erich E
Cell host & microbe 20170525 6
Chronic pulmonary colonization with bacterial pathogens, particularly Pseudomonas aeruginosa, is the primary cause of morbidity and mortality in patients with cystic fibrosis (CF). We observed that β1-integrins accumulate on the luminal membrane of upper-airway epithelial cells from mice and humans with CF. β1-integrin accumulation is due to increased ceramide and the formation of ceramide platforms that trap β1-integrins on the luminal pole of bronchial epithelial cells. β1-integrins downregula ...[more]