WWC3 downregulation correlates with poor prognosis and inhibition of Hippo signaling in human gastric cancer.
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ABSTRACT:
SUBMITTER: Hou J
PROVIDER: S-EPMC5476718 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Publications
WWC3 downregulation correlates with poor prognosis and inhibition of Hippo signaling in human gastric cancer.
OncoTargets and therapy 20170612
The aim of this study was to investigate the clinicopathological significance and biological roles of WWC3 in human gastric cancer (GC). Clinical significance of WWC3 in human GCs was examined by using immunohistochemistry (IHC). WWC3 was downregulated in 48 of 111 human GCs, and its downregulation was associated with advanced stage, positive nodal status, and higher relapse rate. Importantly, WWC3 downregulation correlated with poor survival. It was also found that WWC3 protein expression was d ...[more]
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