The Use of a Multidimensional Measure of Dialysis Adequacy-Moving beyond Small Solute Kinetics.
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ABSTRACT:
SUBMITTER: Perl J
PROVIDER: S-EPMC5477210 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
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The Use of a Multidimensional Measure of Dialysis Adequacy-Moving beyond Small Solute Kinetics.
Perl Jeffrey J Dember Laura M LM Bargman Joanne M JM Browne Teri T Charytan David M DM Flythe Jennifer E JE Hickson LaTonya J LJ Hung Adriana M AM Jadoul Michel M Lee Timmy Chang TC Meyer Klemens B KB Moradi Hamid H Shafi Tariq T Teitelbaum Isaac I Wong Leslie P LP Chan Christopher T CT
Clinical journal of the American Society of Nephrology : CJASN 20170317 5
Urea removal has become a key measure of the intensity of dialysis treatment for kidney failure. Small solute removal, exemplified by Kt/V<sub>urea,</sub> has been broadly applied as a means to quantify the dose of thrice weekly hemodialysis. Yet, the reliance on small solute clearances alone as a measure of dialysis adequacy fails fully to quantify the intended clinical effects of dialysis therapy. This review aims to (<i>1</i>) understand the strengths and limitations of small solute kinetics ...[more]
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