Ontology highlight
ABSTRACT:
SUBMITTER: Kaku H
PROVIDER: S-EPMC5477345 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Kaku Hiroaki H Holodick Nichol E NE Tumang Joseph R JR Rothstein Thomas L TL
Frontiers in immunology 20170620
B-1a cells are innate-like B-lymphocytes producing natural antibodies. Activation-induced cytidine deaminase (AID), a product of the <i>Aicda</i> gene, plays a central role in class-switch recombination and somatic hypermutation in B cells. Although a role for <i>Aicda</i> in B-1a cells has been suggested on the basis of experiments with knock out (KO) mice, whether B-1a cells express <i>Aicda</i>, and if so, which B-1a cell subpopulation expresses <i>Aicda</i>, remains unknown. Here, we demonst ...[more]