Ontology highlight
ABSTRACT:
SUBMITTER: Chang J
PROVIDER: S-EPMC5477513 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Chang Jiang J Tan Wenle W Ling Zhiqiang Z Xi Ruibin R Shao Mingming M Chen Mengjie M Luo Yingying Y Zhao Yanjie Y Liu Yun Y Huang Xiancong X Xia Yuchao Y Hu Jinlin J Parker Joel S JS Marron David D Cui Qionghua Q Peng Linna L Chu Jiahui J Li Hongmin H Du Zhongli Z Han Yaling Y Tan Wen W Liu Zhihua Z Zhan Qimin Q Li Yun Y Mao Weimin W Wu Chen C Lin Dongxin D
Nature communications 20170526
Approximately half of the world's 500,000 new oesophageal squamous-cell carcinoma (ESCC) cases each year occur in China. Here, we show whole-genome sequencing of DNA and RNA in 94 Chinese individuals with ESCC. We identify six mutational signatures (E1-E6), and Signature E4 is unique in ESCC linked to alcohol intake and genetic variants in alcohol-metabolizing enzymes. We discover significantly recurrent mutations in 20 protein-coding genes, 4 long non-coding RNAs and 10 untranslational regions. ...[more]