A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas.

ABSTRACT:

Background

Amplified centrosomes are widely recognized as a hallmark of cancer. Although supernumerary centrosomes would be expected to compromise cell viability by yielding multipolar spindles that results in death-inducing aneuploidy, cancer cells suppress multipolarity by clustering their extra centrosomes. Thus, cancer cells, with the aid of clustering mechanisms, maintain pseudobipolar spindle phenotypes that are associated with low-grade aneuploidy, an edge to their survival. KIFC1, a nonessential minus end-directed motor of the kinesin-14 family, is a centrosome clustering molecule, essential for viability of extra centrosome-bearing cancer cells. Given that ovarian cancers robustly display amplified centrosomes, we examined the overexpression of KIFC1 in human ovarian tumor

SUBMITTER: Mittal K 

PROVIDER: S-EPMC5477851 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature