Ontology highlight
ABSTRACT:
SUBMITTER: Fan G
PROVIDER: S-EPMC7782532 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Fan Guangjian G Sun Lianhui L Meng Ling L Hu Chen C Wang Xing X Shi Zhan Z Hu Congli C Han Yang Y Yang Qingqing Q Cao Liu L Zhang Xiaohong X Zhang Yan Y Song Xianmin X Xia Shujie S He Baokun B Zhang Shengping S Wang Chuangui C
Nature communications 20210104 1
Drug resistance and tumor recurrence are major challenges in cancer treatment. Cancer cells often display centrosome amplification. To maintain survival, cancer cells achieve bipolar division by clustering supernumerary centrosomes. Targeting centrosome clustering is therefore considered a promising therapeutic strategy. However, the regulatory mechanisms of centrosome clustering remain unclear. Here we report that KIFC1, a centrosome clustering regulator, is positively associated with tumor rec ...[more]