Ontology highlight
ABSTRACT:
SUBMITTER: Vareechon C
PROVIDER: S-EPMC5478421 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Cell host & microbe 20170501 5
Neutrophils are the first line of defense against bacterial infections, and the generation of reactive oxygen species is a key part of their arsenal. Pathogens use detoxification systems to avoid the bactericidal effects of reactive oxygen species. Here we demonstrate that the Gram-negative pathogen Pseudomonas aeruginosa is susceptible to reactive oxygen species but actively blocks the reactive oxygen species burst using two type III secreted effector proteins, ExoS and ExoT. ExoS ADP-ribosylat ...[more]