Ontology highlight
ABSTRACT:
SUBMITTER: Caccamo A
PROVIDER: S-EPMC5479312 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Caccamo A A Ferreira E E Branca C C Oddo S S
Molecular psychiatry 20160830 6
The multifunctional protein p62 is associated with neuropathological inclusions in several neurodegenerative disorders, including frontotemporal lobar degeneration, amyotrophic lateral sclerosis and Alzheimer's disease (AD). Strong evidence shows that in AD, p62 immunoreactivity is associated with neurofibrillary tangles and is involved in tau degradation. However, it remains to be determined whether p62 also plays a role in regulating amyloid-β (Aβ) aggregation and degradation. Using a gene the ...[more]