Ontology highlight
ABSTRACT:
SUBMITTER: Yin P
PROVIDER: S-EPMC5479846 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Yin Peiqi P Zhang Ling L Ye Fei F Deng Yao Y Lu Sha S Li Yi-Ping YP Zhang Leiliang L Tan Wenjie W
Scientific reports 20170621 1
Hepatitis C virus (HCV) entry into hepatocytes is a multistep process that represents a promising target for antiviral intervention. The viral envelope protein E1E2 plays a critical role in HCV entry. In this study, we sought to identify peptide inhibitors of HCV by screening a library of overlapping peptides covering E1E2. Screening the peptide library identified several novel anti-HCV peptides. Four peptides from glycoprotein E2 were selected for further investigation. The 50% effective dose ( ...[more]