Ontology highlight
ABSTRACT:
SUBMITTER: Raj I
PROVIDER: S-EPMC5480393 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Raj Isha I Sadat Al Hosseini Hamed H Dioguardi Elisa E Nishimura Kaoru K Han Ling L Villa Alessandra A de Sanctis Daniele D Jovine Luca L
Cell 20170601 7
Recognition between sperm and the egg surface marks the beginning of life in all sexually reproducing organisms. This fundamental biological event depends on the species-specific interaction between rapidly evolving counterpart molecules on the gametes. We report biochemical, crystallographic, and mutational studies of domain repeats 1-3 of invertebrate egg coat protein VERL and their interaction with cognate sperm protein lysin. VERL repeats fold like the functionally essential N-terminal repea ...[more]