S-EPMC5481334 - Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons. - OmicsDI

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Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons.

ABSTRACT: We investigated the influence of genetic variants on atherosclerosis using whole exome sequencing in cases and controls from the autopsy study "Pathobiological Determinants of Atherosclerosis in Youth (PDAY)". We identified a PDAY case group with the highest total amounts of raised lesions (n?=?359) for comparisons with a control group with no detectable raised lesions (n?=?626). In addition to the standard exome capture, we included genome-wide proximal promoter regions that contain sequences that regulate gene expression. Our statistical analyses included single variant analysis for common variants (MAF?>?0.01) and rare variant analysis for low frequency and rare variants (MAF?

SUBMITTER: Hixson JE

PROVIDER: S-EPMC5481334 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Whole Exome Sequencing to Identify Genetic Variants Associated with Raised Atherosclerotic Lesions in Young Persons.

Hixson James E JE Jun Goo G Shimmin Lawrence C LC Wang Yizhi Y Yu Guoqiang G Mao Chunhong C Warren Andrew S AS Howard Timothy D TD Heide Richard S Vander RSV Van Eyk Jennifer J Wang Yue Y Herrington David M DM

Scientific reports 20170622 1

We investigated the influence of genetic variants on atherosclerosis using whole exome sequencing in cases and controls from the autopsy study "Pathobiological Determinants of Atherosclerosis in Youth (PDAY)". We identified a PDAY case group with the highest total amounts of raised lesions (n = 359) for comparisons with a control group with no detectable raised lesions (n = 626). In addition to the standard exome capture, we included genome-wide proximal promoter regions that contain sequences t ...[more]

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