High-resolution profiles of gene expression and DNA methylation highlight mitochondrial modifications during early embryonic development.

ABSTRACT: Well-organized mitochondrial functions and dynamics are critical for early embryonic development and are operated via a large number of mitochondria-related genes (MtGs) encoded by both the nuclear and the mitochondrial genome. However, the mechanisms underlying mitochondrial modifications during the critical window between blastocyst implantation and postimplantation organogenesis are poorly understood. Herein, we performed high-resolution dynamic profiling of MtGs to acquire a more detailed understanding of mitochondrial modifications during early development. Our data suggest that the resumption of mitochondrial mass growth is not only facilitated by increased mitochondrial biogenesis and mitochondrial DNA (mtDNA) replication, but also by the appropriate balance between mitochondrial fi

SUBMITTER: Ren L 

PROVIDER: S-EPMC5481627 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature