Ontology highlight
ABSTRACT:
SUBMITTER: Middelkamp S
PROVIDER: S-EPMC7159919 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Middelkamp Sjors S van Tol Helena T A HTA Spierings Diana C J DCJ Boymans Sander S Guryev Victor V Roelen Bernard A J BAJ Lansdorp Peter M PM Cuppen Edwin E Kuijk Ewart W EW
Science advances 20200415 16
Genomic instability is common in human embryos, but the underlying causes are largely unknown. Here, we examined the consequences of sperm DNA damage on the embryonic genome by single-cell whole-genome sequencing of individual blastomeres from bovine embryos produced with sperm damaged by γ-radiation. Sperm DNA damage primarily leads to fragmentation of the paternal chromosomes followed by random distribution of the chromosomal fragments over the two sister cells in the first cell division. An u ...[more]