Ontology highlight
ABSTRACT:
SUBMITTER: Cai J
PROVIDER: S-EPMC5481840 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Cai Junchao J Fang Lishan L Huang Yongbo Y Li Rong R Xu Xiaonan X Hu Zhihuang Z Zhang Le L Yang Yi Y Zhu Xun X Zhang Heng H Wu Jueheng J Huang Yan Y Li Jun J Zeng Musheng M Song Erwei E He Yukai Y Zhang Li L Li Mengfeng M
Nature communications 20170619
Cancer chemoresistance and metastasis are tightly associated features. However, whether they share common molecular mechanisms and thus can be targeted with one common strategy remain unclear in non-small cell lung cancer (NSCLC). Here, we report that high levels of microRNA-128-3p (miR-128-3p) is key to concomitant development of chemoresistance and metastasis in residual NSCLC cells having survived repeated chemotherapy and correlates with chemoresistance, aggressiveness and poor prognosis in ...[more]