Ontology highlight
ABSTRACT:
SUBMITTER: Wickstrom M
PROVIDER: S-EPMC4674781 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Wickström Malin M Dyberg Cecilia C Milosevic Jelena J Einvik Christer C Calero Raul R Sveinbjörnsson Baldur B Sandén Emma E Darabi Anna A Siesjö Peter P Kool Marcel M Kogner Per P Baryawno Ninib N Johnsen John Inge JI
Nature communications 20151125
The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGMT we investigated cellular regulators of MGMT expression in multiple cancers. Here we show a significant correlation between Wnt signalling and MGMT expression in cancers with different origin and con ...[more]