A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
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ABSTRACT:
SUBMITTER: Manning A
PROVIDER: S-EPMC5482074 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Publications
A Low-Frequency Inactivating <i>AKT2</i> Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning Alisa A Highland Heather M HM Gasser Jessica J Sim Xueling X Tukiainen Taru T Fontanillas Pierre P Grarup Niels N Rivas Manuel A MA Mahajan Anubha A Locke Adam E AE Cingolani Pablo P Pers Tune H TH Viñuela Ana A Brown Andrew A AA Wu Ying Y Flannick Jason J Fuchsberger Christian C Gamazon Eric R ER Gaulton Kyle J KJ Im Hae Kyung HK Teslovich Tanya M TM Blackwell Thomas W TW Bork-Jensen Jette J Burtt Noël P NP Chen Yuhui Y Green Todd T Hartl Christopher C Kang Hyun Min HM Kumar Ashish A Ladenvall Claes C Ma Clement C Moutsianas Loukas L Pearson Richard D RD Perry John R B JRB Rayner N William NW Robertson Neil R NR Scott Laura J LJ van de Bunt Martijn M Eriksson Johan G JG Jula Antti A Koskinen Seppo S Lehtimäki Terho T Palotie Aarno A Raitakari Olli T OT Jacobs Suzanne B R SBR Wessel Jennifer J Chu Audrey Y AY Scott Robert A RA Goodarzi Mark O MO Blancher Christine C Buck Gemma G Buck David D Chines Peter S PS Gabriel Stacey S Gjesing Anette P AP Groves Christopher J CJ Hollensted Mette M Huyghe Jeroen R JR Jackson Anne U AU Jun Goo G Justesen Johanne Marie JM Mangino Massimo M Murphy Jacquelyn J Neville Matt M Onofrio Robert R Small Kerrin S KS Stringham Heather M HM Trakalo Joseph J Banks Eric E Carey Jason J Carneiro Mauricio O MO DePristo Mark M Farjoun Yossi Y Fennell Timothy T Goldstein Jacqueline I JI Grant George G Hrabé de Angelis Martin M Maguire Jared J Neale Benjamin M BM Poplin Ryan R Purcell Shaun S Schwarzmayr Thomas T Shakir Khalid K Smith Joshua D JD Strom Tim M TM Wieland Thomas T Lindstrom Jaana J Brandslund Ivan I Christensen Cramer C Surdulescu Gabriela L GL Lakka Timo A TA Doney Alex S F ASF Nilsson Peter P Wareham Nicholas J NJ Langenberg Claudia C Varga Tibor V TV Franks Paul W PW Rolandsson Olov O Rosengren Anders H AH Farook Vidya S VS Thameem Farook F Puppala Sobha S Kumar Satish S Lehman Donna M DM Jenkinson Christopher P CP Curran Joanne E JE Hale Daniel Esten DE Fowler Sharon P SP Arya Rector R DeFronzo Ralph A RA Abboud Hanna E HE Syvänen Ann-Christine AC Hicks Pamela J PJ Palmer Nicholette D ND Ng Maggie C Y MCY Bowden Donald W DW Freedman Barry I BI Esko Tõnu T Mägi Reedik R Milani Lili L Mihailov Evelin E Metspalu Andres A Narisu Narisu N Kinnunen Leena L Bonnycastle Lori L LL Swift Amy A Pasko Dorota D Wood Andrew R AR Fadista João J Pollin Toni I TI Barzilai Nir N Atzmon Gil G Glaser Benjamin B Thorand Barbara B Strauch Konstantin K Peters Annette A Roden Michael M Müller-Nurasyid Martina M Liang Liming L Kriebel Jennifer J Illig Thomas T Grallert Harald H Gieger Christian C Meisinger Christa C Lannfelt Lars L Musani Solomon K SK Griswold Michael M Taylor Herman A HA Wilson Gregory G Correa Adolfo A Oksa Heikki H Scott William R WR Afzal Uzma U Tan Sian-Tsung ST Loh Marie M Chambers John C JC Sehmi Jobanpreet J Kooner Jaspal Singh JS Lehne Benjamin B Cho Yoon Shin YS Lee Jong-Young JY Han Bok-Ghee BG Käräjämäki Annemari A Qi Qibin Q Qi Lu L Huang Jinyan J Hu Frank B FB Melander Olle O Orho-Melander Marju M Below Jennifer E JE Aguilar David D Wong Tien Yin TY Liu Jianjun J Khor Chiea-Chuen CC Chia Kee Seng KS Lim Wei Yen WY Cheng Ching-Yu CY Chan Edmund E Tai E Shyong ES Aung Tin T Linneberg Allan A Isomaa Bo B Meitinger Thomas T Tuomi Tiinamaija T Hakaste Liisa L Kravic Jasmina J Jørgensen Marit E ME Lauritzen Torsten T Deloukas Panos P Stirrups Kathleen E KE Owen Katharine R KR Farmer Andrew J AJ Frayling Timothy M TM O'Rahilly Stephen P SP Walker Mark M Levy Jonathan C JC Hodgkiss Dylan D Hattersley Andrew T AT Kuulasmaa Teemu T Stančáková Alena A Barroso Inês I Bharadwaj Dwaipayan D Chan Juliana J Chandak Giriraj R GR Daly Mark J MJ Donnelly Peter J PJ Ebrahim Shah B SB Elliott Paul P Fingerlin Tasha T Froguel Philippe P Hu Cheng C Jia Weiping W Ma Ronald C W RCW McVean Gilean G Park Taesung T Prabhakaran Dorairaj D Sandhu Manjinder M Scott James J Sladek Rob R Tandon Nikhil N Teo Yik Ying YY Zeggini Eleftheria E Watanabe Richard M RM Koistinen Heikki A HA Kesaniemi Y Antero YA Uusitupa Matti M Spector Timothy D TD Salomaa Veikko V Rauramaa Rainer R Palmer Colin N A CNA Prokopenko Inga I Morris Andrew D AD Bergman Richard N RN Collins Francis S FS Lind Lars L Ingelsson Erik E Tuomilehto Jaakko J Karpe Fredrik F Groop Leif L Jørgensen Torben T Hansen Torben T Pedersen Oluf O Kuusisto Johanna J Abecasis Gonçalo G Bell Graeme I GI Blangero John J Cox Nancy J NJ Duggirala Ravindranath R Seielstad Mark M Wilson James G JG Dupuis Josee J Ripatti Samuli S Hanis Craig L CL Florez Jose C JC Mohlke Karen L KL Meigs James B JB Laakso Markku M Morris Andrew P AP Boehnke Michael M Altshuler David D McCarthy Mark I MI Gloyn Anna L AL Lindgren Cecilia M CM
Diabetes 20170324 7
To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in <i>AKT2</i> and fasting plasma insulin (FI), a gene in which rare fully penetra ...[more]