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Effects of maternal acrolein exposure during pregnancy on testicular testosterone production in fetal rats.


ABSTRACT: Acrolein has been reported to have diverse toxic effects on various organs, including the reproductive system. However, little is known regarding the effects of maternal acrolein exposure on testicular steroidogenesis in male offspring. The present study investigated the effects of acrolein on fetal testosterone production and associated genes. Pregnant Sprague?Dawley rats were intraperitoneally injected with vehicle (normal saline) or 1, 2 or 5 mg/kg acrolein from gestational day (GD) 14?20, and fetal testes were examined on GD 21. Fetal body and testicular weights were markedly reduced in pups following exposure to high doses of acrolein (5 mg/kg) in late pregnancy. Notably, in utero exposure of 5 mg/kg acrolein significantly decreased the testicular testosterone level and downregulated the expression levels of steroidogenic acute regulatory protein (StAR) and 3??hydroxysteroid dehydrogenase (3??HSD), whereas the levels of other steroidogenic enzymes, including scavenger receptor class B, cholesterol side?chain cleavage enzyme and steroid 17 alpha?hydroxylase/17,20 lyase, were unaffected. Furthermore, the 3??HSD immunoreactive area in the interstitial region of the fetal testes was reduced at a 5 mg/kg dose, whereas the protein expression levels of 4?hydroxynonenalwere dose?dependently increased following maternal exposure to acrolein. mRNA expression levels of insulin?like factor 3, a critical gene involved in testicular descent, were unaltered following maternal acrolein exposure. Taken together, the results of the present study suggested that maternal exposure to high doses of acrolein inhibited fetal testosterone synthesis, and abnormal expression of StAR and 3??HSD may be associated with impairment of the steroidogenic capacity.

SUBMITTER: Yang Y 

PROVIDER: S-EPMC5482093 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature

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Effects of maternal acrolein exposure during pregnancy on testicular testosterone production in fetal rats.

Yang Yuzhuo Y   Zhang Zhe Z   Zhang Hongliang H   Hong Kai K   Tang Wenhao W   Zhao Lianming L   Lin Haocheng H   Liu Defeng D   Mao Jiaming J   Wu Han H   Jiang Hui H  

Molecular medicine reports 20170525 1


Acrolein has been reported to have diverse toxic effects on various organs, including the reproductive system. However, little is known regarding the effects of maternal acrolein exposure on testicular steroidogenesis in male offspring. The present study investigated the effects of acrolein on fetal testosterone production and associated genes. Pregnant Sprague‑Dawley rats were intraperitoneally injected with vehicle (normal saline) or 1, 2 or 5 mg/kg acrolein from gestational day (GD) 14‑20, an  ...[more]

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