Convergent evolution of a modified, acetate-driven TCA cycle in bacteria.
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ABSTRACT:
SUBMITTER: Kwong WK
PROVIDER: S-EPMC5482284 | biostudies-literature | 2017 Apr
REPOSITORIES: biostudies-literature
Publications
Convergent evolution of a modified, acetate-driven TCA cycle in bacteria.
Kwong Waldan K WK Zheng Hao H Moran Nancy A NA
Nature microbiology 20170428
The tricarboxylic acid (TCA) cycle is central to energy production and biosynthetic precursor synthesis in aerobic organisms. There are few known variations of a complete TCA cycle, with the common notion being that the enzymes involved have already evolved towards optimal performance. Here, we present evidence that an alternative TCA cycle, in which acetate:succinate CoA-transferase (ASCT) replaces the enzymatic step typically performed by succinyl-CoA synthetase (SCS), has arisen in diverse ba ...[more]
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