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Biodegradable and biocompatible high elastic chitosan scaffold is cell-friendly both in vitro and in vivo.

ABSTRACT: Biodegradable and biocompatible macromolecule chitosan has been favored for a variety of clinical applications. We reported herein the fabrication of a novel chitosan scaffold with high elasticity. This scaffold can be easily compressed and thus enable the insertion of such scaffold into surgical lesions during minimal invasive surgeries. In addition, this novel scaffold can restore its shape when released. We evidenced that this high elastic scaffold has better biocompatibility than traditional chitosan scaffold. Therefore, this new chitosan material might lead to the manufacture of a variety of novel biodegradable biomedical materials and devices.

SUBMITTER: Pang Y

PROVIDER: S-EPMC5482600 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Biodegradable and biocompatible high elastic chitosan scaffold is cell-friendly both in vitro and in vivo.

Pang Yichuan Y Qin An A Lin Xianfeng X Yang Lin L Wang Qiang Q Wang Zhengke Z Shan Zhi Z Li Shengyun S Wang Jiying J Fan Shunwu S Hu Qiaoling Q

Oncotarget 20170501 22

Biodegradable and biocompatible macromolecule chitosan has been favored for a variety of clinical applications. We reported herein the fabrication of a novel chitosan scaffold with high elasticity. This scaffold can be easily compressed and thus enable the insertion of such scaffold into surgical lesions during minimal invasive surgeries. In addition, this novel scaffold can restore its shape when released. We evidenced that this high elastic scaffold has better biocompatibility than traditional ...[more]

PMID: 28103580

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