Ontology highlight
ABSTRACT:
SUBMITTER: Thompson RM
PROVIDER: S-EPMC5482623 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Thompson Ravyn M RM Dytfeld Dominik D Reyes Leticia L Robinson Reeder M RM Smith Brittany B Manevich Yefim Y Jakubowiak Andrzej A Komarnicki Mieczyslaw M Przybylowicz-Chalecka Anna A Szczepaniak Tomasz T Mitra Amit K AK Van Ness Brian G BG Luczak Magdalena M Dolloff Nathan G NG
Oncotarget 20170501 22
Curative responses in the treatment of multiple myeloma (MM) are limited by the emergence of therapeutic resistance. To address this problem, we set out to identify druggable mechanisms that convey resistance to proteasome inhibitors (PIs; e.g., bortezomib), which are cornerstone agents in the treatment of MM. In isogenic pairs of PI sensitive and resistant cells, we observed stark differences in cellular bioenergetics between the divergent phenotypes. PI resistant cells exhibited increased mito ...[more]