Ontology highlight
ABSTRACT:
SUBMITTER: Perez FA
PROVIDER: S-EPMC548311 | biostudies-literature | 2005 Feb
REPOSITORIES: biostudies-literature
Perez Francisco A FA Palmiter Richard D RD
Proceedings of the National Academy of Sciences of the United States of America 20050131 6
Mutations in the human parkin gene cause autosomal recessive juvenile parkinsonism, a heritable form of Parkinson's disease (PD). To determine whether mutations in the mouse parkin gene (Park2) also result in a parkinsonian phenotype, we generated mice with a targeted deletion of parkin exon 2. Using an extensive behavioral screen, we evaluated neurological function, motor ability, emotionality, learning, and memory in aged Parkin-deficient mice. The behavioral profile of Parkin-deficient mice o ...[more]