Dataset Information

Reproducibility of quantitative indices of lung function and microstructure from ¹²⁹ Xe chemical shift saturation recovery (CSSR) MR spectroscopy.

ABSTRACT:

Purpose

To evaluate the reproducibility of indices of lung microstructure and function derived from ¹²⁹ Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD), and to study the sensitivity of CSSR-derived parameters to pulse sequence design and lung inflation level.

Methods

Preliminary data were collected from five volunteers on three occasions, using two implementations of the CSSR sequence. Separately, three volunteers each underwent CSSR at three different lung inflation levels. After analysis of these preliminary data, five COPD patients were scanned on three separate days, and nine age-matched volunteers were scanned three times on one day, to assess reproducibility.

Results

CSSR-derived alveolar septal thickness (ST) and surface-area-to-volume (S/V) ratio values decreased with lung inflation level (P?Conclusion¹²⁹ Xe CSSR presents a reproducible method for estimation of alveolar septal thickness. Magn Reson Med 77:2107-2113, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

SUBMITTER: Stewart NJ

PROVIDER: S-EPMC5484314 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature

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Publications

Reproducibility of quantitative indices of lung function and microstructure from <sup>129</sup> Xe chemical shift saturation recovery (CSSR) MR spectroscopy.

Stewart Neil J NJ Horn Felix C FC Norquay Graham G Collier Guilhem J GJ Yates Denise P DP Lawson Rod R Marshall Helen H Wild Jim M JM

Magnetic resonance in medicine 20160701 6

<h4>Purpose</h4>To evaluate the reproducibility of indices of lung microstructure and function derived from <sup>129</sup> Xe chemical shift saturation recovery (CSSR) spectroscopy in healthy volunteers and patients with chronic obstructive pulmonary disease (COPD), and to study the sensitivity of CSSR-derived parameters to pulse sequence design and lung inflation level.<h4>Methods</h4>Preliminary data were collected from five volunteers on three occasions, using two implementations of the CSSR ...[more]

PMID: 27366901

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Project description:It is inferred that magnesian non-porphyritic chondrules in the CB (Bencubbin-type) carbonaceous chondrites formed in an impact generated plume of gas and melt at 4562.49 ± 0.21 Ma (Bollard et al., 2015) and could be suitable for the absolute age normalization of relative chronometers. Here xenon isotopic compositions of neutron irradiated chondrules from the CB chondrites Gujba and Hammadah al Hamra (HH) 237 have been analyzed in an attempt to determine closure time of their I-Xe isotope systematics. One of the HH 237 chondrules, #1, yielded a well-defined I-Xe isochron that corresponds to a closure time of 0.29 ± 0.16 Ma after the Shallowater aubrite standard. Release profiles and diffusion properties of radiogenic 129*Xe and 128*Xe, extracted from this chondrule by step-wise pyrolysis, indicate presence of two iodine host phases with distinct activation energies of 73 and 120 kcal/mol. In spite of the activation energy differences, the I-Xe isotope systematics of these two phases closed simultaneously, suggesting rapid heating and cooling (possibly quenching) of the CB chondrules. The release profiles of U-fission Xe and I-derived Xe correlate in the high temperature host phase supporting simultaneous closure of 129I-129Xe and 207Pb-206Pb systematics. The absolute I-Xe age of Shallowater standard is derived from the observed correlation between I-Xe and Pb-Pb ages in a number of samples. It is re-evaluated here using Pb-Pb ages adjusted for an updated 238U/235U ratio of 137.794 and meteorite specific U-isotope ratios. With the addition of the new data for HH 237 chondrule #1, the re-evaluated absolute I-Xe age of Shallowater is 4562.4 ± 0.2 Ma. The absolute I-Xe age of the HH 237 chondrule #1 is 4562.1 ± 0.3 Ma, in good agreement with U-corrected Pb-Pb ages of the Gujba chondrules (Bollard et al., 2015) and HH 237 silicates (Krot et al., 2005). All I-Xe data used here, and in previous estimates of the absolute age of Shallowater, are calculated using 15.7 ± 0.6 Ma value for 129I half-life. The slopes of I-Xe - Pb-Pb correlation lines plotted for different sets of samples for Shallowater normalization are always ≤1. Assuming uranium half-life values are correct; this restricts the half-life of 129I to ≤15.7 Ma.

Dataset Information

Reproducibility of quantitative indices of lung function and microstructure from ¹²⁹ Xe chemical shift saturation recovery (CSSR) MR spectroscopy.

Purpose

Methods

Results

Publications

Reproducibility of quantitative indices of lung function and microstructure from <sup>129</sup> Xe chemical shift saturation recovery (CSSR) MR spectroscopy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Reproducibility of quantitative indices of lung function and microstructure from 129 Xe chemical shift saturation recovery (CSSR) MR spectroscopy.

Purpose

Methods

Results

Publications

Reproducibility of quantitative indices of lung function and microstructure from <sup>129</sup> Xe chemical shift saturation recovery (CSSR) MR spectroscopy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Reproducibility of quantitative indices of lung function and microstructure from ¹²⁹ Xe chemical shift saturation recovery (CSSR) MR spectroscopy.