Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion.

ABSTRACT: New magnetic resonance (MR) molecular imaging techniques offer the potential for noninvasive, simultaneous quantification of metabolic and perfusion parameters in tumors. This study applied a three-dimensional dynamic dual-agent hyperpolarized ¹³C magnetic resonance spectroscopic imaging approach with ¹³C-pyruvate and ¹³C-urea to investigate differences in perfusion and metabolism between low- and high-grade tumors in the transgenic adenocarcinoma of mouse prostate (TRAMP) transgenic mouse model of prostate cancer. Dynamic MR data were corrected for T1 relaxation and RF excitation and modeled to provide quantitative measures of pyruvate to lactate flux (k_PL ) and urea perfusion (urea AUC) that correlated with TRAMP tumor histologic grade.

SUBMITTER: Chen HY 

PROVIDER: S-EPMC5484421 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature