Ontology highlight
ABSTRACT:
SUBMITTER: Gustafson CL
PROVIDER: S-EPMC5484534 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Gustafson Chelsea L CL Parsley Nicole C NC Asimgil Hande H Lee Hsiau-Wei HW Ahlbach Christopher C Michael Alicia K AK Xu Haiyan H Williams Owen L OL Davis Tara L TL Liu Andrew C AC Partch Carrie L CL
Molecular cell 20170511 4
The C-terminal transactivation domain (TAD) of BMAL1 (brain and muscle ARNT-like 1) is a regulatory hub for transcriptional coactivators and repressors that compete for binding and, consequently, contributes to period determination of the mammalian circadian clock. Here, we report the discovery of two distinct conformational states that slowly exchange within the dynamic TAD to control timing. This binary switch results from cis/trans isomerization about a highly conserved Trp-Pro imide bond in ...[more]