PET Tracer ¹⁸F-Fluciclovine Can Detect Histologically Proven Bone Metastatic Lesions: A Preclinical Study in Rat Osteolytic and Osteoblastic Bone Metastasis Models.

ABSTRACT: ¹⁸F-Fluciclovine (trans-1-amino-3-¹⁸F-fluorocyclobutanecarboxylic acid; anti-¹⁸F-FACBC) is a positron emission tomography (PET) tracer for diagnosing cancers (e.g., prostate and breast cancer). The most frequent metastatic organ of these cancers is bone. Fluciclovine-PET can visualize bony lesions in clinical practice; however, such lesions have not been described histologically. Methods: We investigated the potential of ¹⁴C-fluciclovine in aiding the visualization of osteolytic and osteoblastic bone metastases (with histological analyses), compared with ³H-2-deoxy-2-fluoro-D-glucose (³H-FDG), ³H-choline chloride (³H-choline), and ^99mTc-hydroxymethylene diphosphonate (

SUBMITTER: Oka S 

PROVIDER: S-EPMC5485422 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature